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國立屏東大學應用化學系

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教師陳皇州

教師:陳皇州 副教授

 

主要研究方向:蛋白質化學、無機生物化學

 

Tel08-766-3800 ext.33254

 

E-mailkelvin@mail.nptu.edu.tw

 

學歷:國立清華大學化學博士

 

經歷:

國立屏東大學應用化學系 副教授

國立屏東大學教務處課務組 組長

國立屏東教育大學化學生物系 副教授

國立屏東教育大學教務處課務組 組長

國立屏東教育大學化學生物系 助理教授

國立屏東教育大學研發處學術發展組 組長

中央研究院特約博士後研究學者

美國俄亥俄州立大學生物化學系博士後研究學者

中央研究院化學研究所博士後研究

 

近五年執行計畫:

  1. 國立屏東大學培育產學合作教師推動計畫:製備及純化聚谷胺酸之研究 (國立屏東大學,計畫主持人,2015)
  2. 動手做科學教育中心化學工作站計畫(教育部,子計畫主持人,2013-2015)
  3. 藍銅胜肽的合成與探討(國立屏東教育大學-台虹科技公司產學合作計畫,計畫主持人,2012)
  4. 國立屏東教育大學培育產學合作教師推動計畫:醫療級藍銅胜肽製備與生理功能之研究NPUE-AD-101-02 (國立屏東教育大學,計畫主持人,2012)
  5. 亞太教育研究中心-理學院國際共同研究計畫-子計畫(國立屏東教育大學,計畫主持人,2011-2012)
  6. 膜固醇賀爾蒙受體之研究II (2/2)(國科會自然處,計畫主持人,2010-2012)
  7. 亞太教育研究中心-理學院國際共同研究計畫-子計畫(國立屏東教育大學,計畫主持人,2010-2011)
  8. 膜固醇賀爾蒙受體之研究II(國科會中型儀器補助計畫,計畫主持人,2009-2010)
  9. 膜固醇賀爾蒙受體之研究II (1/2)(國科會自然處,計畫主持人,2009-2010)

 

 

代表著作:

國際期刊論文

 

  1. Kelvin H.-C. Chen*, Phimonphan Chuankhayan, Hsin-Hui Wu, Chun-Jung Chen*, Mitsuhiro Fukuda, Steve S.-F. Yu, Sunney I. Chan. The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal that Leu114 regulates a water tunnel. (2015) J. Inorg. Biochem., In press,  (SCI; Impact Factor: 3.444; Ranking: 7/44, 15.9% (Chemistry, Inorganic & Nuclear), Corresponding and first author, Times Cited = 0).

 

  1. Kelvin H.-C. Chen*, Hsin-Hui Wu, Si-Fu Ke, Ya-Ting Rao, Chia-Ming Tu, Yu-Ping Chen, Kuo-Hsuan Kuei, Ying-Siao Chen, Vincent C.-C. Wang, Wei-Chun Kao, Sunney I. Chan. Bacteriohemerythrin bolsters the activity of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath). (2012) J. Inorg. Biochem., 111, 10-17. (SCI; Impact Factor: 3.317; Ranking: 9/43, 20.9% (Chemistry, Inorganic & Nuclear), Corresponding and first author, Times Cited = 11).

 

  1. Sunney I. Chan*, Hiephoa T. Nguyen, Kelvin H.-C. Chen and Steve S.-F. Yu. Over-expression and purification of the Particulate Methane Monooxygenase (pMMO) from Methylococcus capsulatus (Bath). (2011) Methods in Enzymology, 495, 177-193. (SCI, Impact Factor: 2.002, Times Cited = 5)

 

  1. Tsun-Ren Chen*, Hsiu-Pen Lee, Jhy-Der Chen, Kelvin H.-C. Chen (2010) An 18+d iridium dimmer releasing metalloradicals spontaneously. Dalton Trans., 39, 9458-9461. (SCI, Impact Factor: 4.081, Times Cited = 3)

 

  1. Hsiu-Pen Lee, Yi-Fen Hsu, Tsun-Ren Chen*, Jhy-Der Chen, Kelvin H.-C. Chen, Ju-Chun Wang.  (2009)  A Novel Cyclometalated Dimeric Iridium Complex, [(dfpbo)(2) Ir](2) [dfpbo = 2-(3,5-Difluorophenyl) . Inorg. Chem., 48, 4, 1263-1265. (SCI, Impact Factor: 4.657, Times Cited = 11)

 

  1. Kelvin H.-C. Chen*, Sunney I. Chan. (2007) The Structure Biology Studies of Metallic Membrane Protein: Particulate Methane Monooxygenase from Methylococcus Capsulatus (Bath), National Synchrotron Radiation Research Center User’s Research Report, II-121.

 

  1. Steve S.-F. Yu, Cheng-Zhi Ji, Ya-Ping Wu, Tsu-Lin Lee, Chien-Hung Lai, Su-Ching Lin, Zong-Lin Yang, Vincent C.-C Wang, Kelvin H.-C. Chen, Sunney I. Chan*. (2007) The C-Terminal Aqueous-Exposed Domain of the 45 kDa Subunit of the Particulate Methane Monooxygenase (pMMO) in Methylococcus capsulatus (Bath) is a Cu(I) Sponge. Biochemistry, 46, 13762-13774. (SCI, Impact Factor: 3.015, Times Cited = 16)

 

  1. Sunney I. Chan*, Vincent C.-C. Wang, Jeff C.-H. Lai, Steve S.-F. Yu, Peter P.-Y. Chen, Kelvin H.-C. Chen, Chang-Li Chen, Michael K. Chan. (2007) Redox Potentiometric Studies of the Particulate Methane Monooxygenase: Support for a Trinuclear Copper Cluster Active Site. Angrew. Chem. Int. Ed. 46, 12, 1992-1994. (SCI, Impact Factor: 11.261, Times Cited = 77)

 

  1. Steve S.-F. Yu, Kelvin H.-C. Chen, Cheng-Zhi Ji, Chu-Lin Lee, Chien-Hung Lai, Zong-Lin Yang, Sunney I. Chan*. (2006) The XAS Studies of the Copper Ions in the Aqueous-exposed Domains of the 45 kDa Subunit of Particulate Methane Monooxygenase. National Synchrotron Radiation Research Center Activity Report 2006/2007, II, 207.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan*. (2005) X-ray Absorption Spectroscopic Studies of pMMO from Methylococcus capsulatus (Bath) National Synchrotron Radiation Research Center Activity Report 2004/2005, 65-68.

 

  1. Sunney I. Chan*, Kelvin H.-C. Chen, Steve S.-F. Yu, Chang-Li Chen, Simon S.-J. Kuo. (2004) Toward Delineating the Structure and Function of the Particulate Methane Monooxygenase (pMMO) from Methanotrophic Bacteria. Biochemistry, 43, 15, 4421-4430. (SCI, Impact Factor: 3.015, Times Cited = 93)

 

  1. Kelvin H.-C. Chen, Chang-Li Chen, Chiu-Fou Tseng, Steve S.-F. Yu, Shyue Chu Ke, Jyh-Fu Lee, Hiephoa T. Nguyen, Sean J. Elliott, James O. Alben, Sunney I. Chan*. (2004) The Copper Clusters in the Particulate Methane Monooxygenase (pMMO) from Methylococcus capsulatus (Bath). J. Chin. Chem. Soc., 51, 5B, 1081-1098 Feature Article. (SCI, Times Cited = 37)

 

  1. Madhuri S. Vinchurkar, Kelvin H.-C. Chen, Yu-Heng Tseng, Steve S. -F. Yu, Hui-Chi Chiu, Shu-Hua Chien and Sunney I. Chan*. (2004) Polarized ATR-FTIR Spectroscopy of the Membrane-Embedded Domains of the Particulate Methane Monooxygenase. Biochemistry, 43, 42, 13283-13292. (SCI, Impact Factor: 3.015, Times Cited = 15)

 

  1. Chang-Li Chen, Kelvin H.-C. Chen, Shyue Chu Ke, Steve S.-F. Yu, Sunney I. Chan*. (2004) Preparation and characterization of a (Cu,Zn)-pMMO from Methylococcus capsulatus (Bath). J. Inorg. Biochem., 98, 12, 2125-2130. (SCI, Impact Factor: 3.444, Times Cited = 7)

 

  1. Joseph W. Arndt, Kelvin H.-C. Chen, Xuejun Zhong, Joseph A. Krzycki, Michael K. Chan*. (2004) Support for Nickel as the Labile Metal in the A-center of the M. barkeri Acetyl-CoA Decarbonylase/Synthase Complex. J. Chin. Chem. Soc., 51, 5B, 1253-1258. (SCI)

 

  1. Svitlana V. Pavlova, Kelvin H.-C. Chen, Sunney I. Chan*. (2004) Spectroscopic Characterization of the Oxotransfer Reaction from bis-(mu-oxo) Dicopper (III) Complex to Triphenylphosphine. Dalton Trans., 21, 20, 3261-3272. (SCI, Times Cited = 5)

 

  1. Shao-Ching Hung, Chang-Li Chen, Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan*. (2004) The Trinuclear Copper (II) Clusters of the Particulate Methane Monooxygenase from Methanotrophic Bacteria: Electron Paramagnetic Resonance Spectral Simulations. J. Chin. Chem. Soc., 51, 5B, 1229-1244. (SCI, Times Cited = 24)

 

  1. Steve S.-F. Yu, Kelvin H.-C. Chen, Mandy Y.-H. Tseng, Yane-Shih Wang, Chiu-Feng Tseng, Yu-Ju Chen, Ded-Shih Huang*, Sunney I. Chan*. (2003) Production of High Quality pMMO in High Yields from Methylococcus capsulatus (Bath) with a Hollow-Fiber Membrane Bioreactor. J. Bacteriol., 185, 20, 5915-5924. (SCI, Impact Factor: 2.808, Times Cited = 70)

 

  1. Steve S.-F. Yu, Lo-Ying Wu, Kelvin H.-C. Chen, Wen-I Luo, Ded-Shih Huang, and Sunney I. Chan*. (2003) The Stereospecific Hydroxylation of [2-2H2] butane and Chiral Deuterated Butanes by the Particulate Methane Monooxygenase from in Methylococcus capsulatus (Bath). J. Biol. Chem., 278, 42, 40658-40669. (SCI, Impact Factor: 4.573, Times Cited = 35)

 

 

國際研討會論文

 

  1. Kelvin H.-C. Chen et. al. (2015) The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal that Leu114 regulates a water tunnel. National Synchrotron Radiation Research Center (NSRRC) 2015 User’s meeting, Hsinchu, Taiwan.

 

  1. Shiu-Chin Huang, Kelvin H.-C. Chen (2015) Gamma-PGA Production by Bacillus subtilis in Solid-state Fermentation. The 6th NICE conference, Tokyo, Japan.

 

  1. Kelvin H.-C. Chen (2014) Introduction of the Hands-on Science Learning Center at NPTU. The 3rd Taiwan-Korea-Japan DHP Conference. Hyogo, Japan.

 

  1. Yen-Chi Chen, Kelvin H.-C Chen (2013) Human progesterone receptor membrane protein binding characteristics of the component I studied biochemistry. The 5th NICE conference, Pingtung, Taiwan.

 

  1. Kelvin H.-C. Chen, Ya-Hsuan Jao (2013) Environment Acinetobacter baumannii resistance organisms with bamboo charcoal bear body phase analysis. The 5th NICE conference, Pingtung, Taiwan.

 

  1. Kelvin H.-C. Chen, Hsin-Hui Wu, Si-Fu Ke, Ya-Ting Rao, Chia-Ming Tu, Yu-Ping Chen, Kuo-Hsuan Kuei, Ying-Siao Chen, Vincent C.-C. Wang, Wei-Chun Kao, Sunney I. Chan (2012) Bacteriohemerythrin, the helping hands of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath). National Synchrotron Radiation Research Center (NSRRC) 2012 User’s meeting, Hsinchu, Taiwan.

 

  1. Kelvin H.-C. Chen, Szu-Han Chou, Hsin-Hui Wu, Yu-Ping Chen, Ya-Wen Liu, Chih-Yu Hsieh, Si-Fu Ke (2010) Expression, Purification and Biochemical Characterization of Human Progesterone Receptor Membrane Component 1 (PGRMC1). 5th Asian Biological Inorganic Chemistry Conference (AsBIC-IV), Kaohsiung, Taiwan.

 

  1. Shin-Hui Wu, SuChing Lin, Sunney I. Chan, Rita P.Y. Chen, and Kelvin H.-C. Chen (2009) Spectroscopic and Biochemical Characterization of Human Membrane associated Progesterone Receptor Component 1 (PGRMC1_human). Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Pingtung, Taiwan.

 

  1. Shin-Huey Wu, Yu-Ping Chen, Wei-Chung Kao, Vincent C.-C. Wang, Steve S.-F. Yu, Sunney I. Chan and Kelvin H.-C. Chen. (2008) The X-ray crystallographic Studies of Methanol Dehydrogenase from Methylococcus capsulatus (Bath). National Synchrotron Radiation Research Center (NSRRC) 2008 User’s meeting, Hsinchu, Taiwan.

 

  1. Steve S.-F. Yu, Kelvin H.-C. Chen, Madhuri S. Vinchurkar, Sunney I. Chan. (2006) The PmoB C-Terminal Domain of pMMO in Methylococcus capsulatus (Bath) is a Cu(I) Sponge. Gordon Research Conference: Molecular Basis of Microbial One-Carbon Metabolism, Magdalen College, Oxford, UK.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2004) Toward Delineating the Structure and Function of the Particulate Methane Monooxygenase (pMMO) from Methanotrophic Bacteria.  2004 American Society Biochemistry And Molecular Biology Annual Meeting (ASBMB), Boston, Massachusetts, USA.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2003) Characterization of the copper C-cluster of the Particulate Methane Monooxygenase in Methylococcus capsulatus (Bath).  1st Asian Biological Inorganic Chemistry Conference (AsBIC-I) Okasaki, Japan.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2003) Purification of the Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath). 11th International Conference on Bioinorganic Chemistry (ICBIC 11) Carins, Australia.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2003) Characterization of the copper C-cluster of the Particulate Methane Monooxygenase in Methylococcus capsulatus (Bath).  2003 Keystone Symposia, Membrane proteins: Structure and Mechanism. Taos, New Mexico, USA.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2001) The Characterization of the Copper Cluster of the Particulate Methane Monooxygenase in Methylococcus capsulatus (Bath).  Synchrotron Radiation Research Center (SRRC) 7th User’s meeting, Hsinchu, Taiwan.

 

  1. Kelvin H.-C. Chen, Steve S.-F. Yu, Sunney I. Chan. (2000) Dioxygen activation and alkane hydroxylation by the membrane-bound Methane Monooxygenase in Methanotrophic Bacteria.  The Sixth Symposium of the Biophysical Society of Taiwan, Hsinchu, Taiwan.

 

獲獎及榮譽:

  1. 21th國家同步輻射研究中心用戶年會暨研討會生物科學組壁報論文競賽優勝 2015
  2. 日本兵庫教育大學國際訪問研究員獎助2009-2014
  3. 中央研究院短期訪問學人研究獎助2007
  4. 中央研究院特約博士後研究學者暨學術研究經費獎助2005~2007
  5. Journal of the Chinese Chemical Society 年度最佳論文獎2005

 

主要教學科目:

普通生物學、微生物學、蛋白質化學、微生物生化工程、生物物理化學、結構生物學、高等生物化學